![]() (in 1 L dextrose 5% in water over 16 hours) *†Īt the end of the 21 hr protocol, NAC may be discontinued if the following criteria are met: Negative acetaminophen level, INR less than or equal to 1.5, AST or ALT less than 50 IU/L OR, if elevated, declining and approximately 50% of the peak value measured. (in 500 mL dextrose 5% in water over 4 hours) (in 200 mL dextrose 5% in water over 60 minutes) Third Infusion: 100 mg/kg acetylcysteine IV in 1000 mL dextrose 5% in water over 16 hours *†.Second Infusion: 50 mg/kg acetylcysteine IV in 500 mL dextrose 5% in water over 4 hours, immediately followed by:.Loading Dose: 150 mg/kg acetylcysteine IV in 200 mL dextrose 5% in water over 60 minutes immediately followed by:. ![]() Fulminant hepatic failure due to acetaminophen overdose or other hepatotoxic toxins. ![]()
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